Clinical impact of CD49d expression in the context of CLL-IPI categories. (A) OS Kaplan-Meier curves of CLL cases split in the 4 risk categories of the CLL IPI. (B-E) OS curves of CLL cases with homogeneous-negative CD49d expression (homCD49d⁻, light curve) and the merging of homogeneous-positive (homCD49d⁺) and bimodal CD49d (bimCD49d) expression (dark curve) in the context of the low-risk (B), intermediate-risk (C), high-risk (D) and very-high-risk (E) categories of the CLL-IPI. P values refer to the log-rank test.