Amount of CD49d⁺ cells in different tissue compartments and in intraclonal populations from bimCD49d CLL. (A) Percentage of CD49d⁺ cells in paired PB and BM samples from 13 CLL cases with CD49d bimodal expression. Each symbol corresponds to a different case. (B) Amount of CD49d⁺ cells in intraclonal subpopulations with variable reciprocal densities of CXCR4/CD5 expression (CXCR4^dim/CD5^bright and CXCR4^bright/CD5^dim fractions) from 147 CLL cases with CD49d bimodal expression; P values refer to the paired Wilcoxon test.