C587R-mutant hematopoietic cells have altered representation of transcripts encoding RNA metabolism and translation regulators. (A) 14 most significant gene sets identified by Gene Ontology (GO) analysis done on genes underrepresented in C587R/+ platelets compared with +/+ control cells. The dotted line represents the statistical significance at P = .02. (B) Six gene sets identified by GO analysis performed on underrepresented genes in cytoplasmic fraction of C587R/+ naive CD8 T cells. These genes sets were also among the 14 most significant in platelets. The dotted line represents the statistical significance at P = .02. (C) Rotation gene set testing (ROAST) analysis using independent gene sets specific for RNA metabolism, mRNA splicing, and translation on platelets, naive CD8 T cells, and RBCs. The dotted line represents the statistical significance at P = .02. KEGG, Kyoto Encyclopedia of Genes and Genomes; rRNA, ribosomal RNA.