Clonal dynamics (I). Spectrum of CH at baseline (A) and follow-up (B) for individuals with serial molecular data (n = 943). (C) Spectrum of CH at baseline for individuals lacking follow-up. The mutational spectrum for panels A-C was classified as follows: absence of CH, multiple mutated genes, or the presence of a single mutated gene, as indicated. (D) Relation between VAFs at baseline (horizontal axis) and follow-up (vertical axis) for all mutations detected at baseline and/or follow-up visit (n = 715). The gray diagonal line indicates stable VAF. (E) Volcano plot for growth rates of recurrently mutated genes (≥5×). The x-axis displays the mean absolute difference in VAF over time. The y-axis shows the -log₁₀ (P value) indicating the significance of the change in VAF over time (from paired Wilcoxon signed-rank test). The size of each circle corresponds to the overall frequency of the mutation (N) in serial molecular data for 943 individuals, as indicated. The gray horizontal line corresponds to a P value of .05.