Anemia and CH constitute age-related phenomena of the hematopoietic system. (A) Prevalence of anemia according to age in the evaluable Lifelines cohort aged at least 60 years (n = 22,108). (B) Prevalence of CH according to age among cases with anemia (red, n = 635) and control individuals (blue, n = 663). (C) Relative frequencies of mutations detected in the indicated genes across different age categories for the entire cohort (n = 1298). The category of splicing factors includes SF3B1, SRSF2, and U2AF1.