FISH-cryptic MYC and BCL2 rearrangements identified by WGS in DHITsig⁺ DLBCL tumors. (A) Diagram summarizing the occurrence of each genetic event identified in the 20 non–HGBL-DH/TH-BCL2 DHITsig⁺ genomes. The thresholds for MYC and BCL2 immunohistochemistry (IHC) positivity were 40% and 50%, respectively. (B-C) Cryptic BCL2 translocations identified in tumors that were negative for BCL2 rearrangement by breakapart FISH. (D) A cryptic MYC rearrangement identified in a tumor that was negative for MYC rearrangement by breakapart FISH.