Comparison of OS and genomic profile (oncoprint, copy number analysis, and mutation signature) of AH-MCL subgroups: AH-DN vs AH-t. (A) Median survival was significantly longer in AH-DN than in AH-t (48 vs 14 months; P < .001). (B) Oncoprint showing pattern of somatic mutations in AH-DN (n = 31) and AH-t (n = 11) categories. Differences in the 2 groups were not statistically significant. CCND1, NOTCH1, NOTCH2, TP53, NSD2 UBR5, SMARCA4, and RANBP2 mutations were predominant in the AH-DN group, whereas KMT2D, KMT2B, and CACNA1A were predominant in the AH-t group. (C) Copy number gain (blue) and losses (red) are shown between AH-DN and AH-t categories. More frequent copy number losses were noted at chromosome 17p in the AH-DN category. (D) Mutation signature and total mutation burden is shown between the AH-DN and AH-t groups. Mutation signature 6 was predominant in the AH-t group, whereas mutational burden was higher in the AH-DN group compared with the AH-t group (P = not significant).