Figure 2.
Characteristics of leukemia in T2ΔT3, ΔT2T3, and ΔT2ΔT3 mice. (A) WBC counts (i), hemoglobin levels (ii), and platelet counts (iii) of T2ΔT3 (n = 18), ΔT2T3 (n = 10), and ΔT2ΔT3 (n = 36) mice and of Mx1-Cre–Tet2f/fTet3f/w, Tet2f/wTet3f/f, or Tet2f/fTet3f/f mice (Control; n = 14), and spleen weights (iv) of T2ΔT3 (n = 18), ΔT2T3 (n = 10), and ΔT2ΔT3 (n = 24) mice and of control mice (n = 14). (Bi) Representative macroscopic photographs of spleen from leukemic T2ΔT3, ΔT2T3, and ΔT2ΔT3 mice. (Bii) Representative microscopic photographs showing obliteration of the normal spleen architecture in T2ΔT3, ΔT2T3, and ΔT2ΔT3 mice (hematoxylin and eosin stain; original magnification ×10). (Biii) Peripheral blood smear showing blast-like morphology from representative T2ΔT3, ΔT2T3, and ΔT2ΔT3 mice (Wright Giemsa stain; original magnification ×40). *P < .05, **P < .01, ****P < .0001. ns, not significant.

Characteristics of leukemia in T2ΔT3, ΔT2T3, and ΔT2ΔT3 mice. (A) WBC counts (i), hemoglobin levels (ii), and platelet counts (iii) of T2ΔT3 (n = 18), ΔT2T3 (n = 10), and ΔT2ΔT3 (n = 36) mice and of Mx1-Cre–Tet2f/fTet3f/w, Tet2f/wTet3f/f, or Tet2f/fTet3f/f mice (Control; n = 14), and spleen weights (iv) of T2ΔT3 (n = 18), ΔT2T3 (n = 10), and ΔT2ΔT3 (n = 24) mice and of control mice (n = 14). (Bi) Representative macroscopic photographs of spleen from leukemic T2ΔT3, ΔT2T3, and ΔT2ΔT3 mice. (Bii) Representative microscopic photographs showing obliteration of the normal spleen architecture in T2ΔT3, ΔT2T3, and ΔT2ΔT3 mice (hematoxylin and eosin stain; original magnification ×10). (Biii) Peripheral blood smear showing blast-like morphology from representative T2ΔT3, ΔT2T3, and ΔT2ΔT3 mice (Wright Giemsa stain; original magnification ×40). *P < .05, **P < .01, ****P < .0001. ns, not significant.

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