MRD analysis. When feasible, patients in the DFCI trial cohort had samples collected at baseline, after 3 cycles of induction therapy, after 6 cycles of induction therapy, and at various time points following ASCT for MRD analysis using Ig-NGS with ClonoSeq (Adaptive Biotechnologies). In this swimmer’s plot, each horizontal arrow represents an individual patient. Yellow lines denote patients who have relapsed, and the time of relapse is marked by a red x. Green patients are progression-free. Purple triangles represent the timing of ASCT, red circles are MRD-positive samples, and blue circles are MRD-negative samples.