Incidence of disease resolution and mortality over the study period. Cumulative incidence (red) of symptom resolution (A) and hematuria resolution (B) plotted with the proportion of the population who died with ongoing symptoms or hematuria (blue). Among patients who died with ongoing BKPyV-HC, causes of death in this cohort included bleeding events (n = 2), hepatic failure due to vanishing bile duct syndrome (n = 1), Clostridioides difficile colitis (n = 1), GVHD (n = 1), pneumonia (n = 3), acute heart failure (n = 1), and sepsis related to cholecystitis (n = 1). No autopsies were done among this group of patients. At any time point, the height over the blue line represents the proportion of patients who have died during their BKPyV-HC episode (a), the height between blue and red lines represents the proportion of patients who are alive with ongoing symptoms/hematuria (b), and the height under the red line represents the proportion of patients whose symptoms/hematuria have resolved (c).