Bis facilitates apoptosis triggered by anti-CD95 mAb and human tumor necrosis factor–related apoptosis-inducing ligand (TRAIL).

DC were incubated in medium alone or in the presence of anti-CD95 mAb (1 μg/mL) or TRAIL (250 ng/mL) with or without Bis III (20 μmol/L) or CHX (10 μg/mL). After 18 hours, cells were fixed, and DNA was stained with PI and analyzed with use of flow cytometry. The percentage of hypodiploid nuclei (subG1 peak) is indicated on each plot. Data are from 1 experiment representative of 5 done.