Inhibition of LRP by RAP improves survival of infused human recombinant FVIII in vWf knockout mice.

Animals were treated with 200 U/kg human rFVIII with and without preadministration of RAP (40 mg/kg). FVIII antigen (FVIII:Ag) was measured by an ELISA specific for human FVIII. Group means are shown ± SD.