Oral tolerance induction in splenocyte recipients toward pretransplant recipients lymphocytes induces a reversal of the cytokine profile, from a Th1 to a Th2 type of response.

Mice in experimental group A, fed with homogenates of splenocytes derived from recipient strain BALB/c mice manifested increased serum IL10 levels (black bars) and decreased serum IFNγ levels (white bars, A). In contrast, control nontolerant recipients in groups B and C, fed with homogenates prepared from B10.D2 mouse splenocytes or BSA, respectively, showed an increase in serum IFNγ levels and decreased serum IL10 levels (B and C).