Adhesion of transfected B16F10 cells to fibronectin. Tumor cells were treated with thrombin (0.5 U/mL). Bars refer to the mean ± SD of six to eight experiments performed in triplicate. WT, wild-type; PL, mock transfection with empty plasmid; AS12, antisense transfectant; S6-S22, sense transfectants. Difference between mock transfection and sense transfectants were significant at the P< .004 to .04 level (Student’s t-test).