Effects of DCB or bepridil on morphological changes evoked by thrombin. Washed platelets shown in Fig 7 were stimulated by 0.1 U/mL thrombin under unstirring condition. After 15 minutes of incubation, equal volume of 4% glutaraldehyde containing phosphate buffer was added to each aliquot. Electron microscopic analysis was performed as described in Materials and Methods.