Fig. 7.
![Fig. 7. CB2 receptors accounted for the CP 55,940-increased B-cell proliferation. The CB1 receptor antagonist SR 141716 (▪) and the CB2 receptor antagonist SR 144528 (•) were preincubated at indicated concentrations for 30 minutes with purified tonsillar B cells before the addition of 10 nmol/L CP 55,940. B cells were induced to proliferate for 72 hours after ligation of CD40 antigen. Data are expressed taking as 100% the difference between [3H] thymidine uptakes (which corresponded to 15,200 cpm) into B cells activated with CD40 MoAbs with and without 10 nmol/L CP 55,940. *P ≤ .05.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/92/10/10.1182_blood.v92.10.3605/4/blod42205007x.jpeg?Expires=1724243723&Signature=LGsfPi9I0GUghD4GI10BHtp7JtS36-OBTgUUk0X4dQRZ8agiDZkJvpQmWRaPvlv5BZ8dR1NBBsieeEkKLr6JdgiFL6KWhT0fF8R5j0XLtqUsP1MjLQJd2SrbzQeGoia0BSNBkik2oFNxxRbNVaaJUlvw2sGPfVk8SG8rp34Anr7UyVHS0ARvjl-giv2Gro6bsyYULzsNUZbNeT-lOBsvqu7bzYf7buw03HcxqFg554fWw45iymg~XDlj8hmzE8i~~Dr9tyXROQGq9kAqY9DHGYAkri5sLRClcLE8zUiHWG~QxmYZuDLGS2FBm~~VNP~t2xShBXTkRT9fSVidizGL7w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CB2 receptors accounted for the CP 55,940-increased B-cell proliferation. The CB1 receptor antagonist SR 141716 (▪) and the CB2 receptor antagonist SR 144528 (•) were preincubated at indicated concentrations for 30 minutes with purified tonsillar B cells before the addition of 10 nmol/L CP 55,940. B cells were induced to proliferate for 72 hours after ligation of CD40 antigen. Data are expressed taking as 100% the difference between [3H] thymidine uptakes (which corresponded to 15,200 cpm) into B cells activated with CD40 MoAbs with and without 10 nmol/L CP 55,940. *P ≤ .05.
