Anderson Figure 5. Mechanisms of action of novel biologically based therapies targeting multiple myeloma (MM) cells and the BM microenvironment include the following: (A) MM cell G₁ growth arrest and apoptosis; (B) decreased MM-BMSC binding; (C) decreased cytokine activity; (D) decreased cytokine production in BM; (E) decreased angiogenesis; (F) induced host anti-MM immunity.

Abbreviations: BM, bone marrow; BMSC, BM stromal cell; IMiD, immunomodulatory analog; NK, natural killer; VEGF, vascular endothelial growth factor.