Figure 2.
Figure 2. Consecutive rearrangements in the IGK locus, resulting in the two main types of Kde rearrangements. / Most IGK gene rearrangements start with a Vκ-Jκ rearrangement. The functionality of this rearrangement can be disrupted by rearrangement of Kde (kappa deleting element), which deletes the Cκ segment region when the intron recombination signal sequence (intron RSS) is used or deletes the Vκ-Jκ-Cκ region when Kde rearranges to a Vκ gene segment. Both types of Kde rearrangements will delete the IGK gene enhancers (iEκ and 3IEκ), which probably precludes further rearrangements in the IGK locus.

Consecutive rearrangements in theIGKlocus, resulting in the two main types of Kde rearrangements.

Most IGK gene rearrangements start with a Vκ-Jκ rearrangement. The functionality of this rearrangement can be disrupted by rearrangement of Kde (kappa deleting element), which deletes the Cκ segment region when the intron recombination signal sequence (intron RSS) is used or deletes the Vκ-Jκ-Cκ region when Kde rearranges to a Vκ gene segment. Both types of Kde rearrangements will delete the IGK gene enhancers (iEκ and 3IEκ), which probably precludes further rearrangements in the IGK locus.

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