Pathologic findings in the CNS of C57BL/6J mice immunized with MOG35-55. Control mice are shown in panels A-C, while animals treated at 10 days after immunization are shown in panels D-F and at 15 days after immunization are shown in panels G-I. LFB staining of spinal cord shows large areas of demyelination in the control mice (A) but only scattered foci in the MSC-treated mice (D,G) (4 ×). CD3⁺ T cells (B, 20 ×) and macrophages (C) infiltrate the subpial layer of the spinal cord of control mice (10 ×). In contrast, only few T cells (E,H) and macrophages (F,I) are detected in the spinal cord from MSC-treated mice (all 10 ×). Control mice were immunized with MOG35-55 and treated with intravenous PBS alone. Arrows indicate representative histological abnormalities.