RAD-mediated inhibition of in vivo proliferation of HL and ALCL cells. NOD/SCID mice were inoculated subcutaneously with (A) L540cy and (B) Karpas 299 cells, and daily treatment with RAD (5 mg/kg) was started when tumors were palpable. Tumor volume (mean in mm³) was compared between RAD-treated versus control animals. Statistical significance was determined by Mann and Whitney U test (^*P < .05). Arrows define the start of the treatment.