Figure 4.
![Figure 4. HNK overcomes the protective effects of IL-6, IGF-1, and adherence to patient BMSCs. MM.1S cells were treated for 48 hours with indicated concentrations of HNK in the presence or absence of IL-6 (A), IGF (B), or BMSCs derived from 2 patients with MM (C, D). DNA synthesis was determined by measuring [3H]-thymidine incorporation during the last 8 hours of 48-hour cultures. Values represent the mean plus or minus SD of triplicate cultures (*P < .05, **P < .05 inversely significant).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/106/5/10.1182_blood-2005-01-0346/6/zh80170583310004.jpeg?Expires=1724239511&Signature=o0c~FUpxEE8UB2i819fzY8bMYwCqS7SOPfpTVopZVwbHfbpcrjc41Pgz68isWDRoluZY~yREKTUaaBu9pNqhPhEM3m6KJdQTf0wpg73UabXgRbdE7NDpliPfhEs41F0-5ulvAr6bfnG3u2eVaGS9LhU8ilt4w~vOOHSHqjMTzr~6uKCa5wPoFoaYJgOrbxyB-J5mxWW0fTc2nygfXSOJS2vGCzSKQ-Kuas5N9dDUTjhR7ae2Nq4EzR~8G-gMOhZdLE0mY8mPZNXjlsdNXIkcrMxyywBXfgMl4brunBHocNQ3~2MxjFL81fhPpCDeLjz9bncBBtzSodxQboV3Jke~zg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
HNK overcomes the protective effects of IL-6, IGF-1, and adherence to patient BMSCs. MM.1S cells were treated for 48 hours with indicated concentrations of HNK in the presence or absence of IL-6 (A), IGF (B), or BMSCs derived from 2 patients with MM (C, D). DNA synthesis was determined by measuring [3H]-thymidine incorporation during the last 8 hours of 48-hour cultures. Values represent the mean plus or minus SD of triplicate cultures (*P < .05, **P < .05 inversely significant).
