sjTREC levels in patients compared with healthy controls. (A) Box-and-whisker plots for sjTREC levels in peripheral blood CD3⁺ T cells obtained at diagnosis and at 5 points during therapy (▦). Phases of treatment are shown by the bars below (▪ indicates induction; ▨, consolidation; and □, maintenance). sjTREC levels in CD4 and CD8 T cells from age-matched healthy donors are shown in the white box-and-whisker plots. Boxes indicate 2nd and 3rd quartiles; bar, median; and whiskers, range. (B) sjTREC values from individual patients averaged for all timepoints () with respect to age overlaid on those from healthy donors (○). Regression line (solid line) is plotted from healthy donors, and dotted arrow indicates the median sjTREC level in patients with ALL.