BMT of naive rats and subsequent EAE induction with MOG. (A) DA rats (n = 5) without BMT develop a relapsing/remitting type of disease course after immunization with MOG 1-125. Naive DA rats undergoing transplantation with DA BM graft (n = 4) or with ACI BM graft (n = 7) were immunized with MOG 1-125 on day 60 after irradiation. MOG-EAE was induced in all groups. (B) ACI rats without BMT do not develop EAE (n = 4). ACI rats with DA BM graft (n = 8) develop a mild relapsing/remitting disease course if induced 68 days after BMT. Engraftment of ACI BM into ACI rats (n = 4) equally resulted in susceptibility to EAE.