Harris Figure 10. Hypothetical scheme of lymphocyte differentiation.
Harris Figure 10. Hypothetical scheme of lymphocyte differentiation. . / 10A. A postulated common lymphoid stem cell gives rise to both B and T-cell lines. Antigen-independent differentiation results in mature, naìˆve T and B cells that are capable of responding to antigen that binds to their surface antigen receptors (T-cell receptor or surface immunoglobulin (sIg)). Antigen-dependent differentiation results in expanded clones of effector T cells (helper and cytotoxic) and B cells (plasma cells) and memory cells. / 10B. Changes in surface antigen expression characterize stages of T and B-cell differentiation. / 10C. Each stage occurs at a specific anatomic site and architectural location within each lymphoid organ. . / 10D. Many lymphoid neoplasms can be associated with a normal stage of T or B-cell differentiation.
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