Survival of cohorts of 6 mice treated with oligonucleotides alone (left panel) or with cyclophosphamide (CY) (right panel).

All six surviving animals treated with cyclophosphamide and G3139 sacrificed at 90 days with no molecular evidence of disease detected.

Saline=control animals ; AS=antisense oligonucleotide G3139 directed at bcl-2 ; SN=reverse sequence sense control ; MM= 2-base mismatch control.