Molecular interactions determining the fibrin-specificity of plasminogen activators.

Non-fibrin-specific plasminogen activators (streptokinase, two chain urokinase, anisoylated plasminogen-streptokinase activator complex or anistreplase) activate both plasminogen in the fluid phase and fibrin-associated plasminogen. Fibrin-specific plasminogen activators (t-PA, scu-PA and staphylokinase) preferentially activate fibrin-associated plasminogen