Functional evaluation of NKp80 and NKG2A on activated NK cells from macaque. Effect of anti-human NKp80 (A) and NKG2A (B) mAbs on NK-mediated cytotoxicity against FcγR⁺ P815 target cells. Data are from a representative example of a human donor, and a pigtailed and a rhesus macaque. E/T ratio is 20:1. Each graph shows the baseline lysis (blue bars), the maximal lysis triggered by anti-CD16 mAb (red bars), the killing driven by anti-NKp80 and anti-NKp46 mAb (yellow and green bars, respectively, in panel A), and the inhibition of killing by NKG2A cotriggered with anti-CD16 mAb (green bars in panel B). Data are presented as an average (± SD) of experiments conducted on 5 human donors and 5 rhesus and pigtailed macaques.