Figure 8.
Figure 8. GFP-positive muscle fibers are from stem-cell populations of marrow cells. Different populations of marrow cells were infused into C57BL/6 mice after 500 cGy whole-body and 500 cGy lower-extremity radiation. Animals received cardiotoxin injury to their right tibialis anterior muscle 1 week after transplantation, and their muscles were analyzed for the presence of GFP-positive muscle fibers. The numbers of cells injected for whole bone marrow (WBM) were 3 × 106 cells; CD45- and CD45+, 2 × 106 cells; Lineage- and Lineage+, 1.4 × 106 cells; c-Kit+ and c-Kit-, 2.16 × 106 cells; and Sca-1+ and Sca-1-, 8 × 105 cells each. Data represent average ± SE from 3 to 6 animals in each group. All the differences between the positive and negative groups in each population were statistically significant (P < .05). Error bars indicate mean ± standard error.

GFP-positive muscle fibers are from stem-cell populations of marrow cells. Different populations of marrow cells were infused into C57BL/6 mice after 500 cGy whole-body and 500 cGy lower-extremity radiation. Animals received cardiotoxin injury to their right tibialis anterior muscle 1 week after transplantation, and their muscles were analyzed for the presence of GFP-positive muscle fibers. The numbers of cells injected for whole bone marrow (WBM) were 3 × 106 cells; CD45- and CD45+, 2 × 106 cells; Lineage- and Lineage+, 1.4 × 106 cells; c-Kit+ and c-Kit-, 2.16 × 106 cells; and Sca-1+ and Sca-1-, 8 × 105 cells each. Data represent average ± SE from 3 to 6 animals in each group. All the differences between the positive and negative groups in each population were statistically significant (P < .05). Error bars indicate mean ± standard error.

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