: Serial Kaplan-Meier actuarial survival curves for children with acute lymphoblastic leukemia treated from 1968-1997 on successive Children's Cancer Group (CCG) protocols.

The bold line indicates the era in which minimal therapy was achieving a > 50% 10-year survival in children. The broken lines represent the studies that include components of Berlin-Frankfurt-Munster (BFM) derived from the standard BFM'76 ALL study. A gift of WA Bleyer.