cREL amplification and transcript abundance in large B-cell lymphoma subtypes. (A) c-REL transcript abundance in primary DLBCLs with an amplified cREL locus (positive, 15/127 examined tumors) or no cREL amplification (negative, 112/127 examined tumors). (B) c-REL transcript abundance and cREL amplification in DLBCLs arranged by cell of origin (GCB, ABC, and other) and primary MLBCL. Error bars indicate the standard deviation within triplicate experiments.