Recruitment of CD8⁺ cells after poly(I:C) injection is reduced in MC-deficient WBB6F₁-Kit^W/Kit^W-v (Kit^W/Kit^W-v) mice. Poly(I:C) injection in vivo in C57BL/6 mice leads to recruitment of granulocytes with a maximum after 3 hours (A). Numbers of CD4⁺ cells (B) and CD8⁺ cells (C) decreased during the first 3 hours after stimulation and recovered thereafter to reach background levels after 48 hours (^*P < 0.05; ^**P < .001). Five to 10 mice were analyzed for each time point. (D-F) The influx of granulocytes in Kit^+/+ (□), Kit^W/Kit^W-v mice (▦) 3 hours after poly(I:C) injection was comparable. Seven mice of each genotype were analyzed (D). Recovering of CD8⁺ T-cell numbers (F), but not CD4⁺ T-cell numbers (E), 48 hours after poly(I:C) injection was significantly reduced in Kit^W/Kit^W-v mice (▦; ^*P < .05) as compared to Kit^+/+ mice (□) or Kit^W/Kit^W-v mice reconstituted with BMMCs (▩). Five to 8 mice of each genotype were analyzed; n.d. indicates not determined.