R-etodolac induces growth inhibition in MM cell lines. (A) MM.1S (♦), U266 (▪), RPMI8226 (▴), INA-6 (•), and OPM1 (□) MM cells; (B) Dex-sensitive MM.1S (♦) and DEX-resistant MM.1R (▪) MM cells; (C) RPMI8226 (♦) and doxorubicin-resistant RPMI-Dox40 (▴) MM cells; (D) DHL4 (♦) and MM.1S (▴) cells; as well as (E) normal peripheral mononuclear cells from 3 healthy volunteers, no. 1 (♦), no. 2 (▪), and no. 3 (▴) were cultured for 48 hours in the presence of R-etodolac (0-2.5 mM). Cell growth was assessed by MTT assays, and data represent mean (± SD) of quadruplicate cultures.