Effect of rhBAFF, rhAPRIL, and/or SDF-1α on CLL-cell survival. CLL B cells were cultured with (□) or without (▪) NLCs. SDF-1α (•) rhAPRIL (♦) at 500 ng/mL, rhBAFF (▴) at 50 ng/mL, or both (⋄) were added to wells without NLCs at day 0. Also SDF-1α and rhBAFF (⋄) or SDF-1α and rhAPRIL (○) were added to the cultures without NLCs. The mean viability ± SE of replicate wells was determined for each time point indicated on the horizontal axis. A representative example of 3 different CLL patients is presented.