Figure 2.
Bcl-XL with a chemical inhibitor obtained via docking studies. (A) Ribbon model of the NMR structure of Bcl-XL with the docked inhibitor epigallocatechin gallate (EGCG; ball-and-stick). (B) The BH3-binding pocket of Bcl-XL is shown and color coded according to cavity depth: blue, shallow; yellow, deep. The docked conformation of the compound EGCG is also shown (ball-and-stick). The figures were generated with MOLMOL (A) and MOLCAD (B) as implemented in Sybyl (Tripos, Saint Louis, MO). N indicates N-terminus; C, C-terminus.
