Plasma FVIII levels in mice that lack LRP, LDLR, or both. Four weeks after the final pI:pC injection, blood was drawn from control (n = 12), LRP^– (n = 12), LDLR^–/–(n = 9), and LDLR^–/–LRP^– mice (n = 12). Plasma samples were analyzed for FVIII and are plotted as individual values.