Figure 4.
![Figure 4. Hydroxyurea synergistically potentiates AZT-mediated apoptosis and phosphorylation in EBV+ BL-8 cells. (A) BL-8 cells were treated with low doses of AZT (1.25 μg/mL), hydroxyurea (25 μM), or both agents combined for 36 hours and apoptosis was determined by PI annexin staining and FACS analysis. (B) BL-8 cells were incubated for 1 hour or 8 hours with [methyl-3H]-AZT (1.25 μg/mL) alone or in combination with hydroxyurea (25 μM). Methanol extracts were separated in HPLC to purify the AZT-MP. The values represent the mean ± standard deviation of triplicate experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/106/1/10.1182_blood-2004-09-3748/4/zh80130580510004.jpeg?Expires=1724181738&Signature=IWRlWcGV5Hx9d-Hxsq7rN0R05kGelei0GZKym1Q2~zTa0T9z6hEYJsskMlAiqjxWU3datOTY0uzBZHHEsDxsTRzrmub7SHDBtmqiEWkhWR8mTzqSKaCy2lpVY4Pm-JXi6ufSX0wbyEVhHH6SoU0igh3i8hvkd6PZdQQ3wYgIfY6--GvnKG5kE9AKaokQD8XWh4POoWu-aWDL9nnRt16nZ3tkfvmJvTol1bB3JLIWUwR3C~RtTu0QFNOqD1luazuKEOaiyu6hJlJbsKoa5kn1sP-hjvqJiDno1hRmg8YF9jQVak7~jctFnM1qrKWToiK6D0a~Km~EVgg5OaTuXV2g2w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Hydroxyurea synergistically potentiates AZT-mediated apoptosis and phosphorylation in EBV+ BL-8 cells. (A) BL-8 cells were treated with low doses of AZT (1.25 μg/mL), hydroxyurea (25 μM), or both agents combined for 36 hours and apoptosis was determined by PI annexin staining and FACS analysis. (B) BL-8 cells were incubated for 1 hour or 8 hours with [methyl-3H]-AZT (1.25 μg/mL) alone or in combination with hydroxyurea (25 μM). Methanol extracts were separated in HPLC to purify the AZT-MP. The values represent the mean ± standard deviation of triplicate experiments.
