Survival and peripheral blood leukocyte count of mice that received a transplant of FLT3-transduced bone marrow. (A) Kaplan-Meier survival curve and (B) peripheral blood leukocyte count (WBC) for recipients of bone marrow transduced with FLT3-WT, FLT3-ITD, FLT3 D835Y, and FLT3 I836M+R. All mice died or were killed because of disease conditions. The numbers indicate the total number of transplanted EGFP-positive cells. The construct used for transplantation with FLT3-ITD-transduced bone marrow is indicated by “high” and “low” for the high- and the low-expressing construct, respectively. Error bars indicate standard deviation (SD).