DNA glycosylase activity in T-cell subsets during HIV infection. 5-ohC DNA glycosylase activity (A) and 8-oxoG DNA glycosylase activity (B) in CD4⁺ and CD8⁺ T cells from HIV-infected patients. Extracts, isolated from AIDS-patients (n = 7), HIV-infected patients (n = 8), and healthy controls (n = 13), were incubated with 50 fmol duplex oligo containing a single 8-oxoG or 5-ohC residue. The cleavage products were analyzed by 20% denaturing polyacrylamide gel electrophoresis (PAGE) and PhosphorImager scanning. ^*P < .05; ^**P < .01 compared with healthy controls. #P < .05 compared with AIDS patients. Data are given as medians and as 25th to 75th percentiles. □ indicates controls; indicates non-AIDS; ▨ indicates AIDS.