Effect of α₄ and α_L blockade on CLL-cell motility and TEM. (A-B) Effect of blocking antibodies on motility on HUVECs as in Figure 3. (C-D) Effect of these antibodies on TEM. Both anti-integrin mAbs significantly inhibited TEM (P < .005), whereas the effect on motility was only significant in the case of anti-α₄ (P = .004; for α_L, P = .4).