In T-ALL with cryptic t(9;14), N-terminal sequences from the EML1 polypeptide, including a coiled-coil domain, are joined to the same C-terminal ABL sequences present in the more common BCR-ABL1 fusion protein. The resulting 190-kDa EML1-ABL1 fusion protein is a dysregulated tyrosine kinase that transforms Ba/F3 cells. For details, see the article beginning on page .
