Effect of IL-4 cytotoxin on infiltrating Hodgkin lymphoma. H-RS cells (Giemsa staining; A, L1236; B, HD-MyZ) were injected subcutaneously into beige/nude/X-linked BR immunodeficient mice. (C) Representative image of mice developing subcutaneous primary HD-MyZ tumors and axillary and iliac lymph node swellings. (D) Swelling was not detectable in iliac lymph nodes of mice receiving IL4^38-37-PE38KDEL intraperitoneally (200 μg/kg dose). H&E staining of subcutaneous HD-MyZ tumor (E), lung (F), and axillary lymph node (H) harvested from untreated mice. (G) Giemsa staining of aspirated fluids from axillary lymph node of untreated mouse. Original magnifications, × 200 (A-B, E-G) and × 400 (H).