IL-4 cytotoxin mediates tumor regression of subcutaneous Hodgkin lymphoma. Beige/nude/X-linked BR immunodeficient (NIH-III) mice receiving subcutaneous injections of 5 × 106 L1236 (A) or HD-MyZ (B) cells at day 0 were treated with IL438-37-PE38KDEL by intraperitoneal (IP) (twice a day for 5 days; 
) or intratumoral (IT) routes (once a day on alternate days; total of 3 injections) as indicated by arrows (▴, 100 μg/kg; ▪, 500 μg/kg). Control mice are indicated by ○. Tumors were measured with a Vernier caliper, and tumor volume was calculated as described in “Materials and methods.” Each group consisted of 5 to 7 mice, and tumor volumes shown are mean ± SD. Experiments were repeated 2 times in the L1236 tumor model and 4 times in the HD-MyZ tumor model.
