DC activation by native HCV-LPs. ImDCs were exposed to insect cell control preparations (GUS Ctrl), native HCV-LPs, denatured HCV-LPs, or LPS at a final concentration of 10 μg/mL. After 16 hours, DC activation was assessed by flow cytometric analysis of HLA-DR, CD80, CD86, and CD83 cell surface expression (dark line). Histograms corresponding to background expression of the respective cell surface molecules in unexposed DCs are shown as a gray line. A representative result of 3 independent experiments is shown.