Figure 1.
Dose-dependent effect of tipifarnib on spontaneous BFU-E growth. Peripheral blood mononuclear cells (5 × 105/mL) from patients with PV (▪) were plated for 14 days in the presence of various concentrations of tipifarnib (15 nM to 1.5μM) without addition of EPO in the medium and were BFU-E numbered. Results are given as mean ± SD of triplicate BFU-Es. Controls (▦) are BFU-Es obtained from bone marrow mononuclear cells of healthy donors cultured in the presence of EPO 2 IU/mL and tipifarnib (15 nM to 1.5 μM).
