Response of a patient with peripheral T-cell NHL to bortezomib and PegLD. This 64-year-old male with peripheral T-cell non-Hodgkin lymphoma was initially treated with 6 cycles of chemotherapy with cyclophosphamide, adriamycin, vincristine, and prednisone followed by involved field radiation to the mediastinum, resulting in a complete remission. After his disease relapsed he received salvage chemotherapy with ifosfamide, carboplatin, and etoposide, and autologous peripheral blood stem cell transplantation, again resulting in a remission. Upon relapse he received 2 cycles of the histone deacetylase inhibitor depsipeptide with disease progression and then received 6 cycles of bortezomib and PegLD. A complete remission was documented by computed tomography, with resolution of both mediastinal (compare panels A and B) and abdomino-pelvic adenopathy (compare panels C and D) and confirmed by positron emission tomography. Arrows indicate areas of peri-aortic adenopathy in the mediastinum (A) and abdomen (C) that have resolved after therapy (B and D, respectively).