Figure 3.
Induction of apoptosis in Bcr-Abl-positive and -negative cell lines using cell-cycle analysis. FL5.12-p185, LAMA84, HL-60, and U937 cells were treated with the indicated concentrations of MPA and/or imatinib for 24 hours (FL5.12-p185) and 48 hours (all other cell lines). The percent of sub-G1 (apoptotic) cells are shown on each histogram. At least 3 experiments with multiple drug combinations were performed on each cell line. One representative experiment at one selected dose combination is shown.
