Figure 2.
EPAS1 is expressed in renal interstitial cells. Representative kidney sections from hematoxylin and eosin–stained (A) EPAS1–/– (–/–) or (B) EPAS1+/+ (+/+) kidney (×40 fields) and (C) β-galactosidase–stained EPAS1–/– (–/–) kidney (×40 field). Dark-field (top) and bright-field images (bottom) of in situ studies performed on kidney samples from EPAS1+/+ mice after exposure to short-term continuous hypoxia (STCH) with probes specific for (D) and (E) EPAS1 or (F) Epo mRNA. The arrows indicate areas of prominent signal in vascular endothelial cells (VECs), juxtaglomerular complex cells (JGCs), or interstitial cells (ICs) within the kidney. The black bars in panel B and the white bar in panel C correspond to 100 μm; the black bar in panel F corresponds to 200 μm.

EPAS1 is expressed in renal interstitial cells. Representative kidney sections from hematoxylin and eosin–stained (A) EPAS1–/– (–/–) or (B) EPAS1+/+ (+/+) kidney (×40 fields) and (C) β-galactosidase–stained EPAS1–/– (–/–) kidney (×40 field). Dark-field (top) and bright-field images (bottom) of in situ studies performed on kidney samples from EPAS1+/+ mice after exposure to short-term continuous hypoxia (STCH) with probes specific for (D) and (E) EPAS1 or (F) Epo mRNA. The arrows indicate areas of prominent signal in vascular endothelial cells (VECs), juxtaglomerular complex cells (JGCs), or interstitial cells (ICs) within the kidney. The black bars in panel B and the white bar in panel C correspond to 100 μm; the black bar in panel F corresponds to 200 μm.

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