Figure 1.
![Figure 1. CD45RO+ myeloma cells responded to IL-6 by proliferating. (A) Expression profiles of CD45 isoforms in myeloma and normal plasma cells from bone marrow aspirate of a representative myeloma patient and healthy donor were analyzed by flow cytometry. CD38++ CD45+ cells (regions a and b) were analyzed with CD45RA, CD45RB, or CD45RO antibody. (B) Incorporation of [3H]-TdR into normal plasma cells (region a in panel A), and CD45+ and CD45- immature myeloma cells (regions b and c) isolated from a healthy donor and myeloma patient, respectively, by the cell sorter in the presence (▪) or absence (□) of IL-6 (n = 5). FS indicates forward scatter; SS, side scatter.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/105/8/10.1182_blood-2004-10-4083/6/zh80080576950001.jpeg?Expires=1722497096&Signature=yeDMKlZ4lNSqk26wmZLuEY41YNuCWw6JdpoRB3yFv~BFwvqujB~OKJ-H84qCr9eySHraAvjlZkaHu2-qvh1KC2GaHYnbhVe~2KvR~ht7DKSLk5N3BTZUSMEru8Qvp4Ujn01PLfHdgVhm6GS1gUPvvf03uQ-ShEJ~yqg662VU5WS3u2BEACDAc0cUrJc3R1a~RJULcXjgxUWMgRh6wDyuMljOw8U~6jKnXO0~sk5zsgqRMixDiqDqJOwDPijy8XkQDwAm6MkHtYwPEObrU-tg4L4jbDbE~QfSmARvQrgsZi7eH4k3rGvwsLZ-CJXlQReV98mct~Y69HTcRfahQAdr5Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CD45RO+ myeloma cells responded to IL-6 by proliferating. (A) Expression profiles of CD45 isoforms in myeloma and normal plasma cells from bone marrow aspirate of a representative myeloma patient and healthy donor were analyzed by flow cytometry. CD38++ CD45+ cells (regions a and b) were analyzed with CD45RA, CD45RB, or CD45RO antibody. (B) Incorporation of [3H]-TdR into normal plasma cells (region a in panel A), and CD45+ and CD45- immature myeloma cells (regions b and c) isolated from a healthy donor and myeloma patient, respectively, by the cell sorter in the presence (▪) or absence (□) of IL-6 (n = 5). FS indicates forward scatter; SS, side scatter.
