The effect of viral DNA polymerase inhibitors on extracellular HHV-8. BCBL-1 cells were induced into the lytic phase using valproate (0.6 mM; ▧), and the ability of ganciclovir and PFA to inhibit viral production was determined by assaying the amount of infectious virus present in the conditioned medium after a 5-day incubation using the T1H6 reporter cell line. ▪ indicates control cells. Each data point represents the mean ± SD from 6 replicate determinations.