Homology model of VE-cadherin. Structural homology model of murine VE-cadherin ECDs based on the crystal structure of C-cadherin. The epitope of E4G10 (amino acids 4, 5, 7-10) is highlighted in red (A) on the monomer form of VE-cadherin ECD1, and (B) VE-cadherin ECD1 as a trans-dimer. (C) The epitope of BV13 and 10G4 (amino acid sequence 45-56) is highlighted in red on 2 different views of the VE-cadherin ECD1 trans-dimer. (D) The epitope of BV13 and 10G4 (amino acid sequence 45-56) is highlighted in red on cis-interacting VE-cadherin ECD1-2 molecules.